But if they become bothersome, talk with your doctor or pharmacist. Here’s a short list of some of the mild side effects that duloxetine oral capsules can cause. To learn about other mild side effects, talk with your doctor or pharmacist, or read the drug’s prescribing information.
- The estimated background risk of major birth defects and miscarriage for the indicated population is unknown.
- Many kinds of antidepressants are available, and chances are you’ll be able to find one that works well for you.
- If a dose of CYMBALTA is missed, take the missed dose as soon as it is remembered.
- They can review your medications and discuss treatment options with you.
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Examples of drugs that can cause interactions with duloxetine are listed below. Do not take more duloxetine oral capsules than your doctor prescribes. If you’re concerned about how you’ll feel while taking duloxetine, talk with your doctor.
Common questions about Cymbalta
But to help you remember your dose, try taking it at the same time every day. If you have trouble sleeping due to Cymbalta, you might consider taking the drug early in the morning. For details, you can see “Sleep problems” in the “Does Cymbalta have side effects? If you miss a dose of Cymbalta, try to take it as soon as you remember.
Managing Generalized Anxiety Disorder
For details of these clinical trials, see the prescribing information for Cymbalta and Lexapro. The recommended Cymbalta dosage for treating fibromyalgia in adults is 60 mg once per day. After a week, your doctor may increase your dosage to 60 mg once daily. Doses above 60 mg are not recommended for treating this condition. Cymbalta is in a class of drugs called selective serotonin and norepinephrine reuptake inhibitors (SNRIs). It works by boosting the amounts of serotonin and norepinephrine, which are natural substances in the brain.
The model-predicted duloxetine steady state plasma concentrations in pediatric patients 7 to 17 years of age were mostly within the concentration range observed in adult patients and did not exceed the concentration range in adults. Neonates exposed to CYMBALTA and other SNRIs or SSRIs late in the third trimester have developed complications requiring prolonged hospitalization, respiratory support, and tube feeding. These findings are consistent with either a direct toxic effect of the SNRIs or SSRIs, or possibly, a drug discontinuation syndrome.
For most adults, the starting dose is typically 60 mg once daily.It is important to follow the prescribed dosage and take Cymbalta as directed by a healthcare professional. The capsules should be swallowed whole and can be taken with or without food. It is important to give the medication time to take effect, as noticeable improvement in anxiety symptoms methadone: medlineplus drug information may take a few weeks. It is not uncommon for full benefits to be experienced within 2-4 weeks of starting treatment.Cymbalta has been shown to be effective in reducing anxiety symptoms in clinical studies. However, it is important to work closely with a healthcare professional to monitor progress and make any necessary adjustments to the treatment plan.
Inhibition of the metabolism of CYP2C19 substrates is therefore not anticipated, although clinical studies have not been performed. When CYMBALTA was administered (at a dose of 60 mg twice daily) in conjunction with a single 50 mg dose of desipramine, a CYP2D6 substrate, the AUC of desipramine increased 3-fold [see WARNINGS AND PRECAUTIONS]. Under steady-state conditions for CYMBALTA (20 mg qhs) and temazepam (30 mg qhs), the pharmacokinetics of duloxetine were not affected by co-administration. Under steady-state conditions for CYMBALTA (60 mg Q 12 hours) and lorazepam (2 mg Q 12 hours), the pharmacokinetics of duloxetine were not affected by co-administration. Each capsule contains enteric-coated pellets of 22.4, 33.7, or 67.3 mg of duloxetine hydrochloride equivalent to 20, 30, or 60 mg of duloxetine, respectively. These enteric-coated pellets are designed to prevent degradation of the drug in the acidic environment of the stomach.
Cymbalta belongs to a drug class called serotonin-norepinephrine reuptake inhibitors (SNRIs). For treating GAD in children ages 7 to 17 years, the recommended dosage of Cymbalta is 30 mg once per day. After that, your child’s doctor can consider whether the dosage should be increased to 60 mg per day. For treating pain from diabetic neuropathy in adults, the recommended dose of Cymbalta is 60 mg once per day. Doses above 60 mg aren’t recommended for treating this condition. In adults younger than age 65 years, the recommended Cymbalta dosage for treating anxiety is 60 mg once per day.
Suddenly stopping Cymbalta use may increase your risk for discontinuation syndrome, which can cause withdrawal symptoms. We encourage you to talk with your doctor if you experience restlessness, including restless legs, while taking Cymbalta. They may suggest ways to treat this side effect, such as lowering your Cymbalta dose. Or they may recommend that you stop taking Cymbalta and try a different medication for your condition.
CYMBALTA-treated pediatric patients in clinical trials experienced a 0.1 kg mean decrease in weight at 10 weeks, compared with a mean weight gain of approximately 0.9 kg in placebo-treated pediatric patients. The proportion of patients who experienced a clinically significant decrease in weight (≥3.5%) was greater in the CYMBALTA group than in the placebo group (16% and 6%, respectively). Subsequently, over the 4-to 6-month uncontrolled extension periods, CYMBALTA-treated patients on average trended toward recovery to their expected baseline weight percentile based on population data from age-and sex-matched peers. When starting Cymbalta, it is important to follow the recommended dosage as prescribed by a healthcare professional. The starting dose may vary depending on the condition being treated.For most adults, the recommended starting dose for Cymbalta is 60 mg once daily. The dosage may be adjusted based on individual response and tolerability.
Duloxetine (Cymbalta) works by preventing the reuptake of serotonin and epinephrine by nerves after they have been released. A generic drug is an exact copy of the active drug unequal pupils symptoms, causes, and treatment in a brand-name medication. The generic is considered to be as safe and effective as the original drug. You also should not open the capsules to mix them with food or liquids.
They can give you information on how to manage your sodium level and help prevent falls. If you have pain, anxiety, or depression, your medical professional may recommend that you take a prescription drug called Cymbalta. Drinking heavily while taking this drug increases your risk of severe liver injury. Talk to your doctor about how much alcohol you drink before starting duloxetine.
However, fetal weights were decreased at this dose, with a no-effect dose of 10 mg/kg/day (approximately equal to the MRHD in rats and 2 times the MRHD in rabbits). The estimated background risk of major birth defects and miscarriage for the indicated population is unknown. All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2 to 4% and 15 to 20%, respectively. In rats, dietary doses of duloxetine up to 27 mg/kg/day in females (1 time the MRHD given to children) and up to 36 mg/kg/day in males (1.4 times the MRHD given to children) did not increase the incidence of tumors.
It’s possible that the drug may make you more sleepy than usual or cause insomnia (trouble falling or staying asleep). These were common side effects reported by people taking the drug in clinical trials. Some of the mild side effects that Cymbalta may cause are listed below. For information on other mild side effects of the drug, we suggest that you talk with your medical professional or pharmacist. It may also be helpful to refer to the medication guide for Cymbalta.
These lists contain examples of serious side effects that can occur with Cymbalta, with Lexapro, or with both drugs (when taken individually). Although Cymbalta isn’t known to cause dependence or addiction, it’s not always possible to predict whether it could lead to misuse. (Misuse refers to taking alcohol use disorder and timeline of alcohol withdrawal symptoms a drug in a way other than how a doctor prescribes it.) This is because the drug affects your central nervous system (CNS). The CNS is where your brain’s reward pathways (which can be involved with addiction) are located. Clinical trials didn’t show any signs that Cymbalta is addictive.
